Model: C57BL/6N mice 
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days

New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Aging &amp; Longevity

Ezra launches a $5,995 longevity scan with Bryan Johnson, using advanced imaging to detect early signs of aging, cancer, and key health risks.









Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Brain &amp; Neurons

A potentially transformative antibody that inhibits the IL-11 protein increases mouse lifespan by 22% by targeting the same pathways as metformin and rapamycin. 

Antibody prolongs the lifespan of mice by 22%. 

Search Result: Fibrosis

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study

Would You Pay $6,000 to Know What Might Kill You?

Will Interventions that Delay Aging in Animals Work for Humans?

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

Anti-Aging Antibody Significantly Extends Life by 22% in Breakthrough Study