Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Aging &amp; Longevity

Model: C57BL/6N male mice 
Dosage: AIN-93 M diet with 0.025% (15 mg/kg per day) niclosamide for the Old + NL group or 0.050% (30 mg/kg per day) niclosamide for the Old + NH group, starting at 12 months of age to 21 months of age

Drug Approved Against Tapeworms May Counteract Aging, Suggests New Study

New research suggests niclosamide, approved for human use against tapeworms, alleviates frailty and suppresses the protein complex mTOR, which regulates cell growth, in aged mice.

(The drug niclosamide | Hospital Pharmacy Europe)

Niclosamide, an agent approved for human use against tapeworms, alleviates age-related frailty, suppresses mTOR, and activates autophagy in old mice.

Model: 24-month-old male and female C57BL/6J mice
Dosage: 3 mg/kg/day, delivered continuously over 8 weeks

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Scientists show that elamipretide restores muscle and heart function in aging mice but doesn’t affect epigenetic or transcriptomic age.


Cardiovascular

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Aging guru Bryan Johnson shares his latest daily longevity protocol, which he uses to optimize measurements of his body’s aging.

(A futuristic image of Bryan Johnson | YouTube)

Venture capitalist and aging guru Bryan Johnson reveals his latest longevity-focused daily routine for 2025, focusing on sleep, exercise, and eating well.

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Search Result: Endurance

Longevity Prescription

Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study