Model: 6- to 8-week-old male C57BL/6J mice
Dosage: 0.5 mg/kg of isolated mitochondria injected every two days for six injections in the tail vein

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Transplantation of the cell’s powerhouses (mitochondria) improves heart function by restoring mitophagy (the cellular process that clears damaged mitochondria) in a mouse model of cardiac aging.

(An image depicting mitochondria [ovoid structures] in cardiac tissue | NAD.com)

Mitochondrial transplantation improves heart function by restoring the cellular process that clears damaged mitochondria in a mouse model of cardiac aging.

Cardiovascular

The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

Aging &amp; Longevity

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Lowering Age

Six proteomics-based aging clocks (age assessments from large-scale analyses of proteins) agreed that patients treated with the AI-designed drug rentosertib appeared younger.

(A vial containing rentosertib tablets | New York Times)

The AI-designed drug rentosertib was shown to lower biological age across six aging clocks in patients with idiopathic pulmonary fibrosis.

Can Testing Drugs in Five Species Help Us Find Treatments for Healthy Aging?

A new study describes a large cross-species testing system—using species from yeast to mice—to identify promising lifespan-extending drug candidates more efficiently.

(The study tested for lifespan extension in five model organisms | NAD.com)

A new platform tests aging intervention drugs in five animal model species—yeast, worms, flies, fish, and mice.

Model: Male C57BL/6J (B6) mice (15 months old at the start of treatment)
Dosage: Approximately 5 mg/kg/day of S-1-propenyl-L-cysteine (S1PC) was administered orally for 8 months, from 15 to 23 months of age. S1PC was given in chow containing 0.0025% S1PC, with a second experiment using drinking water to confirm the findings.

Researchers found that a compound found in garlic supports healthier muscle aging by boosting cellular defenses linked to longevity and maintaining physical performance.

Search Result: Clinical Trials

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

The Future of Longevity: Could Humans Really Live to 150?

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Making People Younger

Can Testing Drugs in Five Species Help Us Find Treatments for Healthy Aging?

Garlic-Derived Compound Activates a Natural Anti-Aging Pathway That Preserves Muscle Function