A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


Immunity

Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Brain &amp; Neurons

The UN’s Brief on the Biology of Aging

A new brief from the United Nations (UN) Scientific Advisory Board examines the latest developments in geroscience—a field devoted to delaying, preventing, and treating diseases linked to aging.

A new United Nations brief examines how researchers are addressing an aging global population with geroscience—a field seeking to understand how to intervene against aging.

Aging &amp; Longevity

Model: 27-month-old male C57BL/6N mice 
Dosage: 50 mg/kg/day of fisetin for 1 week, followed by no treatment for 2 weeks, followed by another week of treatment

Plant-based molecule fisetin preserves muscle mass and strength in older mice via senolytic action — removal of senescent (dysfunctional) cells.


Study conducted at the University of Colorado Boulder (image: govtech.com) 

Skin &amp; Muscle

Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Search Result: Cancer

Anti-Aging Vaccine Boosts Strength, Memory & NAD+ in New Study

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

The UN’s Brief on the Biology of Aging

Fisetin Fights Frailty: New Study Shows Supplment Preserves Strength

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan