Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

A new human study shows that a procedure involving the replacement of blood plasma with a fresh solution (therapeutic plasma exchange) lowers a measure of how quickly the body is aging (biological age).

(The Buck Institute for Research on Aging | Facebook)

In a first-of-its-kind human trial, participants who underwent therapeutic plasma exchange exhibited significantly lowered biological age.

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<p>Model: Two-month-old male C57BL/6J mice fed a high-fat diet to induce obesity </p>
<p>Dosage: 400 mg/kg/day of NR for eight weeks </p>


Scientists find that NR (nicotinamide riboside) supplementation preserves brown fat tissue in mice, reducing their body weight and maintaining the health of their mitochondria. 

An artist’s rendering of a brown fat cell (image: Alioui Ma/shutterstock.com). 

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Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.  


Principal investigator Nora Kory, PhD, from Harvard University (image: harvard.edu). 

Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

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Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

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