Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Lowering Age

Six proteomics-based aging clocks (age assessments from large-scale analyses of proteins) agreed that patients treated with the AI-designed drug rentosertib appeared younger.

(A vial containing rentosertib tablets | New York Times)

The AI-designed drug rentosertib was shown to lower biological age across six aging clocks in patients with idiopathic pulmonary fibrosis.

Aging &amp; Longevity

Model: Chronically stressed mice 
Dosage: 9 mg/kg/day of L-serine, or 5 mg/kg/day of dasatinib combined with 50 mg/kg/day of quercetin

Supplementing chronically stressed mice with L-serine, an amino acid, counters signs of anxiety and diabetes while diverting age-promoting senescent cells within the brain’s fear center. 

Diabetes &amp; Obesity

Model: 6-week-old ICR mice
Dosage: 250 mg/kg per day or 500 mg/kg per day of glucosamine and 100 mg/kg per day or 200 mg/kg per day of aspirin for either eight (acute alcohol exposure model) or 40 days (chronic alcohol exposure model)

New Study Supports Repurposing Glucosamine Against Liver Aging

A sugar-like compound found in cartilage called glucosamine reduces dysfunctional cells (senescent cells) in the liver and attenuates liver damage from alcohol consumption in mice.

(Glucosamine capsules | MedicalNewsToday)

Glucosamine alleviates liver damage from alcohol consumption in mice, supporting its potential for use against alcoholic liver disease.

Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Skin &amp; Muscle

Model: Male C57BL/6J (B6) mice (15 months old at the start of treatment)
Dosage: Approximately 5 mg/kg/day of S-1-propenyl-L-cysteine (S1PC) was administered orally for 8 months, from 15 to 23 months of age. S1PC was given in chow containing 0.0025% S1PC, with a second experiment using drinking water to confirm the findings.

Researchers found that a compound found in garlic supports healthier muscle aging by boosting cellular defenses linked to longevity and maintaining physical performance.

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Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Making People Younger

Cheap Supplement May Counter Stress-Induced Diabetes, Anxiety, and Brain Senescence, According to New Study

New Study Supports Repurposing Glucosamine Against Liver Aging and Alcoholic Liver Disease

Repurposed Arthritis Drug Counters Muscle Mass Loss with Age, New Study Shows

Garlic-Derived Compound Activates a Natural Anti-Aging Pathway That Preserves Muscle Function