Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Researchers at Case Western Reserve University have shown that late-stage neurodegeneration may be biologically reversible, at least in the right conditions, in mice.

(Case Western Reserve University | Cleveland 19)

Brain &amp; Neurons

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

<p>Participants: Older adults with elevated HbA1c</p>
<p>Dosage: Nicotinamide (250 mg), palmitoylethanolamide (600 mg), oleoylethanolamide (400 mg), and spermidine (8 mg)</p>


In older adults, the combination of nicotinamide, palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and spermidine counters cardiovascular and metabolic aging. 

Study conducted by People Science Inc. (image: prnewswire.com)

Clinical Trials

Andrew Huberman’s Updated Supplement Stack for 2026

Stanford neuroscientist Andrew Huberman’s updated supplement list includes the NAD+ precursor NMN, along with other compounds for sleep and cognitive performance.

Dr. Andrew Huberman’s new supplement stack for 2026 includes NMN, along with supplements supporting sleep, testosterone synthesis, and cognitive function.

Aging &amp; Longevity

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

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Advanced Alzheimer’s Can Be Reversed With NAD+ Restoration, Study Shows in Mice

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

Supplement Combo that Mimics Fasting Counters Aging, New Study Shows

Andrew Huberman’s Updated Supplement Stack for 2026

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain