Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Aging &amp; Longevity

<p>Model: Healthy adults between 21 and 79 years of age<br />
Dosage: 395 mg/kg of bodyweight of (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate monoester (𝛽-hydroxybutyrate ketones) diluted in water and administered once</p>


New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

A new study suggests that supplementing with ketones—molecules the body can use for energy when lacking sugars—prevents cognitive aging when administered in people’s 40s and 50s.

(The study’s principal investigator, Dr. Lilianne R. Mujica-Parodi | Stony Brook University News)

Based on age-related destabilized brain signaling, a new study suggests a critical midlife window where metabolic interventions may stabilize brain signaling.

Brain &amp; Neurons

Pioneering expert in NAD+ metabolism, Shin-Ichiro Imai, MD, PhD, explains the critical role of NAD+ in preventing chronic kidney disease, the ninth leading cause of death worldwide. 


Dr. Shin-Ichiro Imai (image: mspremium.com)

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.  


Principal investigator Nora Kory, PhD, from Harvard University (image: harvard.edu). 

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Search Result: Brain metabolism

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

Expert Explains Role of NAD+ in Preventing Age-Related Kidney Disease

Harvard Scientists Unravel the Role of NAD+ Transporter in Mitigating Age-Related Diabetes

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging