α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaque

A young crab-eating macaque (image: shutterstock.com). 

Aging &amp; Longevity

Does NAD+ (nicotinamide adenine dinucleotide) really help with aging? A team of international scientists reviews the latest and ongoing clinical trials.

Part of the research team, including Dr. Evandro Fei Fang (middle), from the University of Oslo and Akershus University Hospital in Norway (image: med.uio.no). 

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp. 


Stanford University scientist and corresponding author on the new study, Dr. Anne Brunet (image: labxchange.org). 

Brain &amp; Neurons

Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Search Result: Brain Function

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

Anti-Aging Breakthrough: Stem Cells Reverse Signs of Aging in Monkeys

NAD+ and Aging: What the Latest Research Says

How to Take Care of Your Aging Brain Cells: Stanford Study Insights

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging