<p>Participants: Older adults at risk for dementia. </p>
<p>Dosage: 2 g/day of DHA </p>


While it entered the brain, two years of high-dose supplementation revealed no cognitive protection from pure docosahexaenoic acid (DHA) in older adults without dementia.


Brain &amp; Neurons

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

<p>Model: 11-month-old male C57BL/6J mice </p>
<p>Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally</p>


Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Does NAD+ (nicotinamide adenine dinucleotide) really help with aging? A team of international scientists reviews the latest and ongoing clinical trials.

Part of the research team, including Dr. Evandro Fei Fang (middle), from the University of Oslo and Akershus University Hospital in Norway (image: med.uio.no). 

Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Search Result: spinal aging

New USC Study Reveals Popular Omega-3 Supplement Fails to Protect the Brain

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

NAD+ and Aging: What the Latest Research Says

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study