Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Lowering Age

Six proteomics-based aging clocks (age assessments from large-scale analyses of proteins) agreed that patients treated with the AI-designed drug rentosertib appeared younger.

(A vial containing rentosertib tablets | New York Times)

The AI-designed drug rentosertib was shown to lower biological age across six aging clocks in patients with idiopathic pulmonary fibrosis.

Aging &amp; Longevity

Bryan Johnson’s “Clone”: Where the Sci-Fi Ends and the Science Begins

The biohacker says his “newborn” clone could supply young blood, test experimental treatments, and eventually grow replacement organs.

(Bryan Johnson says he’s cloned himself, which could supply young blood, help test experimental treatments, and eventually grow replacement organs. | Futurism)

Model: Skin, arterial, and lens tissue from donors between the ages of 20 and 25 and also 75 
Dosage: 5 µM solution of CMLase, incubated overnight

Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

An engineered enzyme reverses age-related protein damage that researchers have long thought irreversible in human eye, skin, and artery tissues.

(A bioengineered enzyme [purple structure] cleaves a prevalent type of AGE [brown glob] on protein residues that are part of protein filaments [dull green chains] | The Scientist)

A bioengineered enzyme reverses age-related protein damage, long thought of as irreversible damage, in human lens, skin, and artery tissues.

Basic Research

Model: Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.
Dosage: Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of Kluyveromyces fragilis yeast extract, 350 mg of Saccharomyces cerevisiae yeast extract, or a placebo.

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

Cellular reprogramming, an innovative age-reversal technology, stimulates the regeneration of heart cells after a heart attack in mice. 

Search Result: reversing age

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Making People Younger

Bryan Johnson’s “Clone”: Where the Sci-Fi Ends and the Science Begins

New Research: Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

New Age-Reversing Tech Helps Heart Regenerate, Scientists Find