Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Brain &amp; Neurons

Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

David Sinclair: DNA Tagging, rather than DNA Damage, Drives Aging and Is Reversible

Sinclair’s theory proposes that aging occurs due to the loss of epigenetic information — patterns of DNA molecular tags that influence gene activity — which can be restored to a more intact, youthful state.

(Harvard University | blog.logomyway.com)

Harvard professor David Sinclair’s Information Theory of Aging posits that epigenetic information loss facilitates aging.

Epigenetics

Model: NAD+-deficient mice
Dosage (oral): 400 mg/kg of nicotinamide riboside (NR)

Chinese scientists enhance the fertility of middle-aged mice with nicotinamide riboside (NR) by addressing the cellular metabolic deficits associated with aging ovaries.

4-cell embryos from the ovaries of mice given NR. 

 Explore the findings of a new study revealing the potential of NR (nicotinamide riboside) in enhancing female reproductive lifespan and promoting fertility in middle age. Discover the impact of NAD (nicotinamide adenine dinucleotide) supplementation on reproductive health and the promising advancements in fertility research. Read more on NAD.

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle Age - NAD

Metabolism

Cell Reprogramming: True Age Reversal Technology

A gene manipulation technique called cellular programming extends the lifespan of mice and reverses signs of aging in multiple studies, leading to large financial investments in this new technology.  


A stem cell visualized under the microscope with fluorescence. (shutterstock.com | DrimaFilm)

Search Result: restoring vision

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

David Sinclair: DNA Tagging, rather than DNA Damage, Drives Aging and Is Reversible

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle-Age

The Emergence of Cellular Reprogramming: True Age Reversal Technology