Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Aging &amp; Longevity

Elevating the naturally occurring molecule NAD+ (nicotinamide adenine dinucleotide) improves memory and corrects gene-splicing patterns in a worm and a mouse model for dementia. 

Senior author on the study, Dr. Evandro Fang (front left), with some students (image: evandrofanglab.com)

Brain &amp; Neurons

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes 

On 60 Minutes, Peter Attia reveals how performance, prevention, and emotional resilience contribute to aging well. 

Participants: Healthy middle-aged to older adults (average age: ~53 years)
Dosage: 1,000 mg/day of urolithin A for 28 days

Supplementing healthy adults with urolithin A —a compound produced by our gut bacteria— counters signs of age-related immune system decline.  

Principal investigator Dr. Florian R. Greten (image: hessen-schafft-wissen.de).

Search Result: reducing age

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

New Research: Correcting Gene Splicing with NAD+ Boosts Memory

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes

Urolithin Supplement Counters Immune System Aging, New Human Trial Shows