San Francisco scientists find that the FDA-approved drug octreotide, a growth hormone inhibitor, may restore processing speed and mental agility in aged beagles.

Brain &amp; Neurons

Model: Eight-week-old male C57BL/6J mice treated with 400 mg/kg/day of D-galactose via intraperitoneal injection for 12 weeks to induce accelerated aging.
Dosage: 400 mg/kg/day of Antarctic krill oil administered by oral gavage for 12 weeks, alongside D-galactose treatment. A comparison group received 400 mg/kg/day of fish oil under the same conditions.

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

Daily krill oil supplementation preserves muscle strength, endurance, and mitochondrial health in mice with accelerated aging, outperforming fish oil.

Skin &amp; Muscle

University of Southern California (USC) scientists help to uncover why human intelligence declines with age, pointing to a newly discovered cellular target.


The principal investigator on the study, Dr. Michael Bonaguidi (image: usc.edu).

Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells under a microscope | NAD.com)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

Search Result: protein

Growth Hormone Blocker Sharpens Thinking in Aging Dogs, New Study Finds

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

What Causes Age-Related Intelligence Decline? A New Study Points to Immature Brain Cells

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%