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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

<p><span style="font-weight: 400;">Model: 5xFAD mouse model for Alzheimer’s disease </span></p>
<p><span style="font-weight: 400;">Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks </span></p>


Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Brain &amp; Neurons

<p>Model: Six adults who received intravenous NAD+ and eight adults who received intravenous NR</p>
<p>Dosage: 500 mg of intravenous NAD+ or 500 mg of intravenous NR daily for four consecutive days</p>


Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

A Stanford study supports the short-term safety of NAD+ and NR infusion therapies, and participants who received NR infusions exhibited significantly lower HbA1c (a blood test that reflects average blood sugar over two to three months).

(An IV bag containing a solution with NAD+ | Crete Fertility Centre)

A Stanford human trial provides the first data supporting the safety of NAD+ IV and NR IV therapies.

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

<p>Model: 8-month-old female Swiss mice</p>
<p>Dosage: 200 µL of aged-derived fecal suspension administered orally three days per week for two weeks</p>


New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Spanish scientists unveil data showing that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

(A depiction of the intestines filled with gut microbes | Northwestern Medicine)

Spanish scientists show that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

Search Result: pain

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Common Joint Health Supplement May Progress Dementia, New Study Finds

Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

Top Evidence-Based Interventions to Lower Biological Age

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan