Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Aging &amp; Longevity

Model: Aged C57B/6 mice (between 18-25 months old) 
Dosage: 5 mg/kg/day of ABT-263 was fed to mice while 50 mg/kg/day of dichloroacetate and metformin were injected. For lifespan, they were administered for five consecutive days, followed by a two-day intermission, then an additional five consecutive days, followed by a 6-week intermission.

The combination of dichloroacetate, metformin, and ABT-263 eliminates cancer cells and age-promoting senescent cells while improving endurance and extending lifespan in mice. 


The study was led by Dr. Irina Conboy (image: berkeley.edu). 

How to Slow Aging: 7 Tips from a Danish Aging Expert

Danish aging expert Morten Scheibye-Knudsen shares seven ways to slow aging, including taking NR (nicotinamide riboside) and the diabetes medication metformin.

(Professor Morten Scheibye-Knudsen | BBC Science Focus)

Danish aging expert Morten Scheibye-Knudsen does things like taking NR and metformin to slow his biological aging

Model: Male Wistar rats 
Dosage: 1.5 g/kg/day of orally administered glycine for 5 months

Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

A new gene network-based framework predicts the potential of existing drugs to confer pro-longevity effects.

A new gene network-based framework predicts already-approved repurposable drugs that may either confer pro-longevity benefits or age-accelerating effects.

Search Result: mitochondrial health

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

Drug Combo Targets Cancer and Senescent Cells to Prolong the Lifespan of Mice, New Study Shows

How to Slow Aging: 7 Tips from a Danish Aging Expert

Glycine Extends Life & Counters Brain and Muscle Degeneration, New Study Shows

New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential