Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Metabolism

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

Transplanting a population of “young” stem cells from old mice prolongs the lifespan of middle-aged mice and delays manifestations of aging. 

Search Result: middle-age

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Ergothioneine Boosts NAD+, Mitigates Muscle Aging, and Prolongs Life, New Study Shows

New Study Shows Stem Cells Stop Aging and Prolong Life