Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Skin &amp; Muscle

Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Aging &amp; Longevity

Model: Old (17- to 19-month-old) C57BL6 mice 
Dosage: 14 mg/mg/day of rapamycin in food for 5 months

A purported longevity drug, rapamycin, alters immune cells associated with cancer and reduces brain inflammation in mice. 

Immunity

Model: Old male mice
Dosage: 100 mg/kg/day of ALA administered in drinking water

Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

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