Model: Otherwise healthy adults aged 40 and older
Dosage: 15 g of the multi-ingredient supplement dissolved in up to 500 mL of water or juice, given each day orally for six months

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

A six-month human trial found that a multi-ingredient nutritional supplement improved vascular health, reducing arterial stiffness and lowering systolic blood pressure.

(An image depicting increased arterial stiffness [measured with pulse-wave velocity] and blood pressure, along with reduced flow-mediated dilation in aged blood vessels | NAD.com)

A six-month randomized trial found that a multi-ingredient supplement improved vascular health markers, including arterial stiffness and blood pressure.

Cardiovascular

Model: Eight-week-old male C57BL/6J mice treated with 400 mg/kg/day of D-galactose via intraperitoneal injection for 12 weeks to induce accelerated aging.
Dosage: 400 mg/kg/day of Antarctic krill oil administered by oral gavage for 12 weeks, alongside D-galactose treatment. A comparison group received 400 mg/kg/day of fish oil under the same conditions.

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

Daily krill oil supplementation preserves muscle strength, endurance, and mitochondrial health in mice with accelerated aging, outperforming fish oil.

Skin &amp; Muscle

Model: Eight-week-old C57BL/6J mice treated with 300 mg/kg/day of D-galactose by subcutaneous injections for eight weeks
Dosage: 100 mg/kg/day of NMN in drinking water for eight weeks and 5 × 10 5 hUC-MSCs suspended in 150 µL of PBS via tail vein injection on the first day of weeks five through seven

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

Combining NMN with umbilical cord–derived stem cells improved motor and cognitive function while reducing markers of immune aging in mice with chemically induced aging.

(An image of human umbilical cord-derived mesenchymal stem cells under a microscope | NAD.com)

NMN with a stem cell therapy reduced markers of immune aging and improved coordination and memory performance in mice with chemically induced aging-like changes.

Immunity

Model: Apoe−/− C57BL/6J mice fed a high-fat diet
Dosage: 1 × 109 CFU per 0.1 mL of Bacteroides uniformis administered to mice via oral gavage for 12 weeks and 25 mg/kg of pentadecanoic acid via oral gavage three times per week for eight weeks

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Researchers identified pentadecanoic acid, a gut-bacteria-produced metabolite, that lowered LDL cholesterol and limited arterial plaque buildup in mice.

(A depiction of various gut bacteria in the intestines | NAD.com)

A gut bacterial metabolite reduced arterial plaque buildup by about 50% in mice, revealing a potential link between gut microbes and cholesterol regulation.

A new scientific review questions how much researchers actually know about fasting’s ability to enhance cellular recycling—particularly in humans.

The spherical structure depicts an autophagolysosome. 

Search Result: human studies

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

Krill Oil Preserves Muscle Strength and Mitochondrial Health During Accelerated Aging

NMN Enhances Stem Cell Therapy’s Effects on Immune Aging in Latest Study

New Study: Gut Bacteria Metabolite Reduces Arterial Plaque Burden by 50%

Does Fasting Really Trigger Autophagy? New Study Challenges Popular Longevity Belief