Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Aging &amp; Longevity

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes 

On 60 Minutes, Peter Attia reveals how performance, prevention, and emotional resilience contribute to aging well. 

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Columbia University scientists find that inflammation increases the risk of common chronic age-related diseases only in people from industrialized populations. 

Columbia University in New York City (image: Columbia.edu). 

Search Result: high blood pressure

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

The Inflammation Myth: New Insights on Aging