Model: 22-month-old male C57BL/6NIH mice 
Dosage: 400 mg/kg of NR for eight weeks, administered in food

Treating aged mice with the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) improves memory and reduces pro-inflammatory immune cells.

Senior members of the research team, Dr. Bruce R. Troen and Dr. Kenneth L. Seldeen (image: buffalo.edu).  

Brain &amp; Neurons

How to Support Muscle Function with Age: Top Evidence-Based Supplements

Data suggest certain supplements, such as L-carnitine, vitamin D, and essential minerals, support muscle function and physical performance in adults of advanced age.

Researchers from University College London review data supporting that supplements, like vitamin D, L-carnitine, and essential minerals, support muscle function during aging.

Skin &amp; Muscle

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes 

On 60 Minutes, Peter Attia reveals how performance, prevention, and emotional resilience contribute to aging well. 

Aging &amp; Longevity

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Search Result: heart aging

NAD+ Booster Restores Brain Immune Cells & Improves Memory, New Study Reveals

How to Support Muscle Function with Age: Top Evidence-Based Supplements

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing