Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

Aging &amp; Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Model: 24-month-old male C57BL/6J mice 
Dosage: 1% w/v of betaine for three weeks

The naturally occurring compound betaine is elevated in healthy adults after long-term exercise and mitigates signs of aging in mice. 

Immunity

Participants: Healthy male adults between the ages of 18 and 50 
Dosage: 714 mg/day of nicotinamide and 19 mg/day of pyridoxine for nine days

In a randomized human trial, combining nicotinamide with vitamin B6 increases stem cell activation and muscle-growth capacity in response to exercise. 

Search Result: fiber

High Protein Intake Promotes Aging by Lowering NAD+ Levels

How to Boost Mitochondrial Density and Quality for Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

“Exercise in a Pill”? Betaine Supplement Shows Anti-Aging Benefits

NAD+ Booster and Vitamin B6 Activate Stem Cells to Counter Muscle Shrinkage, New Studies Show