New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

A new gene network-based framework predicts the potential of existing drugs to confer pro-longevity effects.

A new gene network-based framework predicts already-approved repurposable drugs that may either confer pro-longevity benefits or age-accelerating effects.

Aging &amp; Longevity

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

<p>Participants: Prefrail older adults</p>
<p>Dosage: 50 mg/day of losartan for at least 8 weeks</p>


Losartan, a common blood pressure medication, increases the survival rate of mice and improves the metabolic outlook of pre-frail older adults. 

Principal Investigator of the study, Dr. Peter M. Abadir (image: jhu.edu).

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Brain &amp; Neurons

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

Search Result: drugs

New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

Top Evidence-Based Interventions to Lower Biological Age

New Johns Hopkins Study: FDA-Approved Losartan May Extend Lifespan

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain