<p><span style="font-weight: 400;">Model: Male Wistar rats </span></p>
<p><span style="font-weight: 400;">Dosage: 1.5 g/kg/day of orally administered glycine for 5 months </span></p>


Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

Aging &amp; Longevity

<p><span style="font-weight: 400;">Model: C57BL/6J mice </span></p>
<p><span style="font-weight: 400;">Dosage: Eating only within an 8-hour window and fasting for 16 hours (~20% caloric deficit may be required) </span></p>


Restricting food intake for 16 hours a day improves the health of female mice and moderately prolongs the life of male mice. 

The principal investigators of the study (from left to right): Dr. Carla Green, Dr. Victoria Acosta-Rodriguez, and Dr. Joseph Takahashi (image: dallasnews.com). 

<p><span style="font-weight: 400;">Model: SAMP8 mice </span></p>
<p><span style="font-weight: 400;">Dosage: ~25 mg/kg/day of PQQ or PQI administered in food </span></p>


Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


<p>Model: 699 European adults with an average age of 63.11 years</p>


Longest Aging Clock Study to Date Shows Robust Improvement in Mortality Risk Prediction

A new study provides evidence that using aging clocks based on molecular tagging patterns on DNA (epigenetic aging clocks) to take multiple age readings across time outperforms taking single measurements in predicting mortality.

(The study’s principal investigator, Luigi Ferrucci | LinkedIn)

An Institute for Research on Aging study provides evidence that using epigenetic aging tests at multiple time points predicts mortality better than a single measurement.

Search Result: death

Glycine Extends Life & Counters Brain and Muscle Degeneration, New Study Shows

16-Hour Intermittent Fasting Improves Health and Longevity, New Study Confirms

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Longest Aging Clock Study to Date Shows Robust Improvement in Mortality Risk Prediction