Model: 6-week-old ICR mice
Dosage: 250 mg/kg per day or 500 mg/kg per day of glucosamine and 100 mg/kg per day or 200 mg/kg per day of aspirin for either eight (acute alcohol exposure model) or 40 days (chronic alcohol exposure model)

New Study Supports Repurposing Glucosamine Against Liver Aging

A sugar-like compound found in cartilage called glucosamine reduces dysfunctional cells (senescent cells) in the liver and attenuates liver damage from alcohol consumption in mice.

(Glucosamine capsules | MedicalNewsToday)

Glucosamine alleviates liver damage from alcohol consumption in mice, supporting its potential for use against alcoholic liver disease.

Aging &amp; Longevity

Model: Old (17- to 19-month-old) C57BL6 mice 
Dosage: 14 mg/mg/day of rapamycin in food for 5 months

A purported longevity drug, rapamycin, alters immune cells associated with cancer and reduces brain inflammation in mice. 

Immunity

How to Slow Aging: 7 Tips from a Danish Aging Expert

Danish aging expert Morten Scheibye-Knudsen shares seven ways to slow aging, including taking NR (nicotinamide riboside) and the diabetes medication metformin.

(Professor Morten Scheibye-Knudsen | BBC Science Focus)

Danish aging expert Morten Scheibye-Knudsen does things like taking NR and metformin to slow his biological aging

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

A new gene network-based framework predicts the potential of existing drugs to confer pro-longevity effects.

A new gene network-based framework predicts already-approved repurposable drugs that may either confer pro-longevity benefits or age-accelerating effects.

Search Result: chronic inflammation

New Study Supports Repurposing Glucosamine Against Liver Aging and Alcoholic Liver Disease

Rapamycin Elevates Immune Cells That Can Battle Cancer Cells, New Study Shows

How to Slow Aging: 7 Tips from a Danish Aging Expert

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential