<p>Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks </p>
<p>Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks</p>


High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

<p data-start="152" data-end="322"><strong data-start="152" data-end="162">Model:</strong> Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.</p>
<p data-start="324" data-end="441"><strong data-start="324" data-end="335">Dosage:</strong> Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.</p>


Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

<p>Model: Naturally aged 24-month-old C57BL/6 mice </p>
<p>Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months </p>


Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

<article class="text-token-text-primary w-full focus:outline-none [--shadow-height:45px] has-data-writing-block:pointer-events-none has-data-writing-block:-mt-(--shadow-height) has-data-writing-block:pt-(--shadow-height) [&amp;:has([data-writing-block])&gt;*]:pointer-events-auto [content-visibility:auto] supports-[content-visibility:auto]:[contain-intrinsic-size:auto_100lvh] scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]" dir="auto" tabindex="-1" data-turn-id="request-68faafe5-c214-8328-a645-d982c8e85808-32" data-testid="conversation-turn-56" data-scroll-anchor="true" data-turn="assistant">
<div class="text-base my-auto mx-auto pb-10 [--thread-content-margin:--spacing(4)] thread-sm:[--thread-content-margin:--spacing(6)] thread-lg:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)">
<div class="[--thread-content-max-width:40rem] thread-lg:[--thread-content-max-width:48rem] mx-auto max-w-(--thread-content-max-width) flex-1 group/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn" tabindex="-1">
<div class="flex max-w-full flex-col grow">
<div class="min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-1" dir="auto" data-message-author-role="assistant" data-message-id="4886ec11-c716-4535-bbf9-133201ac8d7a" data-message-model-slug="gpt-5">
<div class="flex w-full flex-col gap-1 empty:hidden first:pt-[1px]">
<div class="markdown prose dark:prose-invert w-full break-words light markdown-new-styling">
<p data-start="97" data-end="197">Model: Aged mice (18 months old, C57BL/6 strain) and aged rhesus macaques (18–21 years old).</p>
<p data-start="97" data-end="197">Dosage: Mice received 100 µg of EVs^ABPC via tail vein injection twice per week for 4 weeks.<br data-start="297" data-end="300" data-is-only-node="" />Rhesus macaques received 200 µg/kg of EVs^ABPC intravenously once per week for 20 weeks.</p>
</div>
</div>
</div>
</div>
<div class="z-0 flex min-h-[46px] justify-start"></div>
<div class="mt-3 w-full empty:hidden">
<div class="text-center"></div>
</div>
</div>
</div>
</article>
<div class="pointer-events-none h-px w-px" aria-hidden="true" data-edge="true"></div>


Scientists Discover Deer Antler Stem Cells That Reverse Aging in Mice and Monkeys

Researchers discover that deer antler stem cells can restore bone density, slow aging, and reverse biological age in mice and primates.

NAD+ (nicotinamide adenine dinucleotide) may contribute to healthy cellular aging by enhancing biological energy flow, according to the newly formulated energy resistance principle.


Search Result: cell senescence

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing COX7RP Improves Energy Production and Extends Lifespan

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

Scientists Discover Deer Antler Stem Cells That Reverse Aging in Mice and Monkeys

Boosting NAD+ May Defy Aging by Enhancing Energy Flow, According to a New Theory