Model: 20-month-old female C57BL/J mice 
Dosage: 10 nmol/kg/day of semaglutide

Semaglutide extends mouse lifespan and targets signs of aging, such as diminished NAD+, while mimicking the anti-aging effects of caloric restriction (consuming fewer calories). 


The study was led by Dr. Danica Chen (image: berkeley.edu). 

Aging &amp; Longevity

Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Skin &amp; Muscle

Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Model: C57BL/6J mice 
Dosage: Eating only within an 8-hour window and fasting for 16 hours (~20% caloric deficit may be required)

Restricting food intake for 16 hours a day improves the health of female mice and moderately prolongs the life of male mice. 

The principal investigators of the study (from left to right): Dr. Carla Green, Dr. Victoria Acosta-Rodriguez, and Dr. Joseph Takahashi (image: dallasnews.com). 

Japanese scientists have found that reducing NAD+ (nicotinamide adenine dinucleotide) transport into mitochondria within the fat tissue of mice induces metabolic dysregulation and obesity. 

Search Result: blood glucose

Semaglutide (Ozempic) Prolongs Lifespan & Boosts NAD+ in Mice, New Study Shows

Repurposed Arthritis Drug Counters Muscle Mass Loss with Age, New Study Shows

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

16-Hour Intermittent Fasting Improves Health and Longevity, New Study Confirms

NAD+ Transporter Prevents Obesity Caused by Aging: New Study Shows