Model: 8-month-old female Swiss mice
Dosage: 200 µL of aged-derived fecal suspension administered orally three days per week for two weeks

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Spanish scientists unveil data showing that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

(A depiction of the intestines filled with gut microbes | Northwestern Medicine)

Spanish scientists show that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

Aging &amp; Longevity

Peter Fedichev’s Physics-Based Approach to Aging: A New Longevity Framework

Peter Fedichev describes aging as a three-variable system of stress (from physical, psychological, or molecular stressors), noise (small random biological fluctuations), and damage (cumulative wear-and-tear).

Peter Fedichev has proposed a physics-based framework for aging, encompassing stress, noise (small random biological fluctuations), and damage (cumulative wear-and-tear).

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

What Is Mosaic Aging? How Organs Age at Different Rates

A new framework proposes that the patchwork nature of aging, where different organs deteriorate at different speeds, may hold the key to understanding the ultimate cause of death.

(University of Glasgow logo | Scotland.org)

A new framework proposes that aging occurs unevenly in cells, tissues, and organs, and that targeting the fastest-aging tissues may extend lifespan.

Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Search Result: biological aging

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Peter Fedichev’s Physics-Based Approach to Aging: A New Longevity Framework

Rapamycin and Exercise: New Study Finds Potential Performance Decline

What Is Mosaic Aging? How Organs Age at Different Rates

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice