Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Cardiovascular

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

According to French scientists, no organ system appears as vulnerable to aging as the cardiovascular system, and anti-aging therapeutics may help mitigate the effects of cardiovascular disease.

(The principal investigator behind the review, aging researcher Guido Kroemer | Olympiad in Cardiovascular Medicine)

Anti-aging therapeutics may prevent and slow age-related cardiovascular dysfunction.

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults. 

An ultrasound of the carotid artery with arrows pointing to plaques (image: avicennacardiology.com). 

Search Result: atherosclerosis

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

New Study Reveals: High-Dose Supplement Shrinks Arterial Plaque by 36%