NAD+ (nicotinamide adenine dinucleotide) may contribute to healthy cellular aging by enhancing biological energy flow, according to the newly formulated energy resistance principle.


Aging &amp; Longevity

Model: Male Sprague-Dawley rats 
Dosage: 400 mg/kg of magnesium L-theanine and 600 mg/kg of nicotinamide riboside administered orally for 40 days

Scientists find that treating rats with magnesium L-theanine and nicotinamide riboside (NR) counteracts stress-induced metabolic, gut, and liver aging. 

Study conducted by researchers from Firat University in Turkey (image: turkeyuniversity.org)

In remembrance of Jane Goodall: The science-backed lifestyle factors that likely contributed to her long life and sound mind.  

Jane Goodall, PhD (image: thenationalnews.com).

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

Metabolism

Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Search Result: antioxidant

Boosting NAD+ May Defy Aging by Enhancing Energy Flow, According to a New Theory

New Research: Magnesium, L-Theanine, NAD+ Combo Counters Stress Aging

Remembering Jane Goodall: The Simple Habits That Kept Her Mind Sharp for 91 Years

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging