Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

A combined treatment of NMN with 78c (a small molecule that inhibits an NAD+-degrading enzyme) enhances the effects of the anti-cancer CAR-T cell therapy in aged mice and human cells.

(A CAR-T cell [red] attacking a cancer cell [blue] | Crown Bioscience Blog)

Cancer

Anti-Aging Breakthrough? Harvard's David Sinclair Predicts Age-Reversing Pill by 2035

A leading thinker in the field of aging research, Dr. David Sinclair, shares insights on the rapid pace of advancements in aging research and predicts the availability of age-reversing pills within the next 10 years.

(Dr. David Sinclair believes an age-reversing pill is under development | YouTube)

Harvard’s Dr. David Sinclair believes an age-reversing pill may become available within a decade and that researchers may find a way to one day double human lifespan.

Aging &amp; Longevity

While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice. 


The study was funded by the National Institute on Aging, one of the National Institutes of Health (NIH). 

Immunity

A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Search Result: age reversal

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

Anti-Aging Breakthrough? Harvard’s David Sinclair Predicts Age-Reversing Pill by 2035

Anti-Aging NAD+ Precursor Supplement May Promote Anxiety, New Study Shows

Anti-Aging Vaccine Boosts Strength, Memory & NAD+ in New Study

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows