<p>Model: Young acquired niacin dependency (ANDY) mice. </p>
<p>Dosage: 30 mg/kg/day of niacin </p>


Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

Life Biosciences reports preliminary visual-field improvements in two of three glaucoma patients treated with the experimental therapy developed by Dr. David Sinclair’s Harvard team, ER-100.

Aging &amp; Longevity

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Lowering Age

Six proteomics-based aging clocks (age assessments from large-scale analyses of proteins) agreed that patients treated with the AI-designed drug rentosertib appeared younger.

(A vial containing rentosertib tablets | New York Times)

The AI-designed drug rentosertib was shown to lower biological age across six aging clocks in patients with idiopathic pulmonary fibrosis.

Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

How to Slow Aging: 7 Tips from a Danish Aging Expert

Danish aging expert Morten Scheibye-Knudsen shares seven ways to slow aging, including taking NR (nicotinamide riboside) and the diabetes medication metformin.

(Professor Morten Scheibye-Knudsen | BBC Science Focus)

Danish aging expert Morten Scheibye-Knudsen does things like taking NR and metformin to slow his biological aging

Search Result: age reversal

NAD+ Depletion Shortens Lifespan in Mice—but Restoring NAD+ Reverses Health Decline: New Mayo Clinic Study

David Sinclair’s Experimental Cell-Rejuvenation Therapy Shows Early Vision Signals in First Human Trial

Aging Clocks Applied to Human Trial Data Support AI-Designed Drug Making People Younger

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

How to Slow Aging: 7 Tips from a Danish Aging Expert