Model: Two-month-old male C57BL/6J mice fed a high-fat diet to induce obesity 
Dosage: 400 mg/kg/day of NR for eight weeks

Scientists find that NR (nicotinamide riboside) supplementation preserves brown fat tissue in mice, reducing their body weight and maintaining the health of their mitochondria. 

An artist’s rendering of a brown fat cell (image: Alioui Ma/shutterstock.com). 

Diabetes &amp; Obesity

The latest scientific research indicates that both resistance and aerobic exercise are necessary for maximizing longevity and promoting overall health. 

Aging &amp; Longevity

NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Model: Humans with an average age of 40 years
Dosage: Initial 250 mg of NR per day increased by 250 mg per week so that 1 gram per day of NR was reached by the end of the first month; 1 gram per day of NR for the remainder of the five-month study duration

NAD+ Supplement Increases Muscle Mitochondria: Finland Study

The supplement NR raises blood NAD+ and muscle mitochondria levels while improving the gut’s bacterial composition in humans.

(The Study’s Principal Investigator, Eija Pirinen | wiki.oroboros.at)

NR supplementation over a five-month period more than doubles blood NAD+, increases muscle mitochondrial biogenesis, and improves gut microbial composition.

In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

Search Result: White Adipose Tissue

NAD+ Precursor NR Preserves Longevity-Promoting Cells, New Study Shows

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NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

NAD+ Supplement Increases Muscle Mitochondria and Beneficial Gut Bacteria: Finland Study

Caloric Restriction Decreases Inflammation in Humans