Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Aging &amp; Longevity

Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


NAD+ is “The Future” of Longevity: What Celebrities are Doing to “Never Age”

Celebrities like Hailey Bieber, Jennifer Aniston, and Shannon Sharpe have endorsed NAD+ therapy, and studies suggest it could be an effective anti-aging intervention. 

We can’t get NAD+ directly from food, but some foods provide the materials necessary for our cells to make NAD+.  

An example of an NAD+ boosting meal, consisting of chicken breast and green lentils. 

Search Result: Vitamin B3

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Longevity Prescription

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

NAD+ is “The Future” of Longevity: What Celebrities are Doing to “Never Age”

What Foods Are High in NAD+?