<p><span style="font-weight: 400;">Model: SAMP8 mice </span></p>
<p><span style="font-weight: 400;">Dosage: ~25 mg/kg/day of PQQ or PQI administered in food </span></p>


Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


Aging &amp; Longevity

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Human trials report that GlyNAC and exercise regimens improve dysfunction of the cell’s powerhouses (mitochondria), inflammation, muscle strength, and cognition.

(Some GlyNAC tablets above the chemical structure of GlyNAC | Vitamin Retailer)

GlyNAC supplementation and exercise alleviate mitochondrial dysfunction, lower inflammation, increase muscle strength, and bolster cognition.

Skin &amp; Muscle

Cellular reprogramming, an innovative age-reversal technology, stimulates the regeneration of heart cells after a heart attack in mice. 

Cardiovascular

<p>Participants: Sedentary older adults </p>
<p>Dosage: 6 mg/week of rapamycin </p>


In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Search Result: USC

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

New Age-Reversing Tech Helps Heart Regenerate, Scientists Find

Rapamycin and Exercise: New Study Finds Potential Performance Decline