NAD+ (nicotinamide adenine dinucleotide) levels were lower among older adults with frailty—an age-related condition associated with increased vulnerability to disability, disease, and death.

Skin &amp; Muscle

The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

Aging &amp; Longevity

Scientists find that meloxicam preserves muscle mass and strength in aged mice while sustaining mitochondrial function and activating multiple molecules associated with longevity. 


Model: Male C57BL/6J (B6) mice (15 months old at the start of treatment)
Dosage: Approximately 5 mg/kg/day of S-1-propenyl-L-cysteine (S1PC) was administered orally for 8 months, from 15 to 23 months of age. S1PC was given in chow containing 0.0025% S1PC, with a second experiment using drinking water to confirm the findings.

Researchers found that a compound found in garlic supports healthier muscle aging by boosting cellular defenses linked to longevity and maintaining physical performance.

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Search Result: USC

NAD+ Levels are Low Among Individuals with Frailty, New Japanese Study Shows

The Future of Longevity: Could Humans Really Live to 150?

Repurposed Arthritis Drug Counters Muscle Mass Loss with Age, New Study Shows

Garlic-Derived Compound Activates a Natural Anti-Aging Pathway That Preserves Muscle Function

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows