Model: Old male mice
Dosage: 100 mg/kg/day of ALA administered in drinking water

Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Aging &amp; Longevity

Model: 8-month-old female Swiss mice
Dosage: 200 µL of aged-derived fecal suspension administered orally three days per week for two weeks

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Spanish scientists unveil data showing that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

(A depiction of the intestines filled with gut microbes | Northwestern Medicine)

Spanish scientists show that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Approved Human Study Sets Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

In a major proving ground test for the longevity field, the FDA has given its approval for a human trial for a gene therapy attempting a near-total rejuvenating reset of cells.

(David Sinclair, Michael Ringel, Sharon Rosenzweig-Lipson, and Jerry McLaughlin of Life Biosciences | Longevity.technology)

The FDA has greenlighted Life Biosciences’ first human trial testing whether their gene therapy can confer a near-total rejuvenating reset of cells.

Clinical Trials

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Search Result: Tumor

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

FDA Greenlights Life Biosciences’ Human Study, Setting Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions