Participants: Healthy male adults between the ages of 18 and 50 
Dosage: 714 mg/day of nicotinamide and 19 mg/day of pyridoxine for nine days

In a randomized human trial, combining nicotinamide with vitamin B6 increases stem cell activation and muscle-growth capacity in response to exercise. 

Skin &amp; Muscle

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques. 

A young crab-eating macaque (image: shutterstock.com). 

Aging &amp; Longevity

Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

The plant-based compound Harmine counteracts the cellular aging triggered by sleep deprivation in animal models and human cells.

Study conducted at the Leibniz Institute on Aging. 

Cornell and UPenn scientists find that mice introduced to the wild as infants age faster than lab mice, but what does this mean for humans?


Search Result: Transcription

NAD+ Booster and Vitamin B6 Activate Stem Cells to Counter Muscle Shrinkage, New Studies Show

Anti-Aging Breakthrough: Stem Cells Reverse Signs of Aging in Monkeys

Nicotinamide + EGCG Reboot Autophagy and Ease Hallmarks of Brain Aging

Scientist May Have Discovered a New Drug that Makes Up for Lost Sleep

Do Humans Age Like Mice? New Study Reveals Surprising Similarities