Can Testing Drugs in Five Species Help Us Find Treatments for Healthy Aging?

A new study describes a large cross-species testing system—using species from yeast to mice—to identify promising lifespan-extending drug candidates more efficiently.

(The study tested for lifespan extension in five model organisms | NAD.com)

A new platform tests aging intervention drugs in five animal model species—yeast, worms, flies, fish, and mice.

Aging &amp; Longevity

Model: 6-week-old ICR mice
Dosage: 250 mg/kg per day or 500 mg/kg per day of glucosamine and 100 mg/kg per day or 200 mg/kg per day of aspirin for either eight (acute alcohol exposure model) or 40 days (chronic alcohol exposure model)

New Study Supports Repurposing Glucosamine Against Liver Aging

A sugar-like compound found in cartilage called glucosamine reduces dysfunctional cells (senescent cells) in the liver and attenuates liver damage from alcohol consumption in mice.

(Glucosamine capsules | MedicalNewsToday)

Glucosamine alleviates liver damage from alcohol consumption in mice, supporting its potential for use against alcoholic liver disease.

Model: SAMP8 mice (5 months old) and C57BL/6 mice (16 months old)
Dosage: 1.5 mg/kg of urolithin A was administered by intraperitoneal injection three times per week (Monday, Wednesday, and Friday) for 8 weeks.

Study shows that urolithin A preserves memory and cognitive function during aging when treatment begins before age-related decline, but does not reverse cognitive impairment once it is established.

Brain &amp; Neurons

Repurposing Erectile Dysfunction Pills for Longevity

Some people are taking erectile dysfunction medications like Cialis and Viagra for more than sex—rather, to help them live longer.

(Tablets of the erectile dysfunction drugs Cialis and Viagra | Prostate Prognosis)

People have started repurposing erectile dysfunction medications, such as Cialis and Viagra, to help them live longer.

In the largest study of its kind, Viennese scientists analyzed over 25, 000 human tissue slices with AI to determine the architectural changes that occur with aging and how to predict disease. 


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Can Testing Drugs in Five Species Help Us Find Treatments for Healthy Aging?

New Study Supports Repurposing Glucosamine Against Liver Aging and Alcoholic Liver Disease

Urolithin A Preserves Memory During Aging When Treatment Begins Early, Study Shows

Repurposing Erectile Dysfunction Pills for Longevity

Researchers Pull the Strings of Artificial Intelligence to Measure Aging: New Study