Model: Old male mice
Dosage: 100 mg/kg/day of ALA administered in drinking water

Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Aging &amp; Longevity

Participants: Healthy, overweight older adults 
Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks

Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

Cellular reprogramming, an innovative age-reversal technology, stimulates the regeneration of heart cells after a heart attack in mice. 

Cardiovascular

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Search Result: Skin Cancer

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows

Anti-Aging Spermidine Boosts Immune System, New Study Shows

New Age-Reversing Tech Helps Heart Regenerate, Scientists Find

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research