Can Testing Drugs in Five Species Help Us Find Treatments for Healthy Aging?

A new study describes a large cross-species testing system—using species from yeast to mice—to identify promising lifespan-extending drug candidates more efficiently.

(The study tested for lifespan extension in five model organisms | NAD.com)

A new platform tests aging intervention drugs in five animal model species—yeast, worms, flies, fish, and mice.

Aging &amp; Longevity

Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Longevity Medicine’s Peptides Craze: Evidence, Delivery Challenges, and Expert Opinions

Advocates say peptides offer significant benefits against aging, while researchers warn that these claims outpace the evidence.

(Peptides are often injected with a syringe | Harvard Health)

Proponents say peptides offer significant effects against aging, while skeptical scientists say these claims outpace the evidence.

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Model: Skin, arterial, and lens tissue from donors between the ages of 20 and 25 and also 75 
Dosage: 5 µM solution of CMLase, incubated overnight

Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

An engineered enzyme reverses age-related protein damage that researchers have long thought irreversible in human eye, skin, and artery tissues.

(A bioengineered enzyme [purple structure] cleaves a prevalent type of AGE [brown glob] on protein residues that are part of protein filaments [dull green chains] | The Scientist)

A bioengineered enzyme reverses age-related protein damage, long thought of as irreversible damage, in human lens, skin, and artery tissues.

Search Result: Skin

Can Testing Drugs in Five Species Help Us Find Treatments for Healthy Aging?

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

Longevity Medicine’s Peptides Craze: Evidence, Delivery Challenges, and Expert Opinions

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

New Research: Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue