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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Harvard: Microbiome Depletion Rejuvenates the Aging Brain

Harvard researchers find that aged mice lacking gut bacteria exhibit a brain more like that of young mice. 

The Principal Investigator of the study, Dr. Lee Rubin (image: harvard.edu). 

Brain &amp; Neurons

<p>Model: 11-month-old male C57BL/6J mice </p>
<p>Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally</p>


Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

<p>Model: Female New Zealand white rabbits</p>
<p>Dosage: 20 mg/kg of fisetin (the authors did not state the administration route).</p>


Fisetin Combats Heart Disease by Eliminating Senescent Cells

Fisetin reduces susceptibility to a heart condition called atrial fibrillation (AF) and eliminates age-promoting senescent cells in aged rabbits.  

On the right is Principal Investigator Gideon Koren, MD (image: brownhealth.org).

Search Result: Senolytic

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Top Evidence-Based Interventions to Lower Biological Age

New Harvard Study: Microbiome Depletion Rejuvenates the Aging Brain

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

Natural Compound Fisetin Combats Heart Disease by Eliminating Senescent Cells: New Brown University Study