New Data Shows Combining Two Therapies Doubles Lifespan in Mouse Model

Immorta Bio, a biotech company, released results showing that combining its vaccine and stem cell therapy remarkably doubled lifespan in a mouse model of aging.

The biotech company, Immorta Bio, presented data showing a remarkable doubling of lifespan in a mouse model of aging with a combination of its vaccine and stem cell therapy.

Industry

Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Brain &amp; Neurons

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Aging &amp; Longevity

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

The theory says our brain allocates resources to energy-consuming senescent cells at the body’s expense, accounting for gray hair, muscle shrinkage, and other signs of aging.

Search Result: Quercetin

Biotech Company Unveils Data Showing Combining Its Two Therapies Doubles Lifespan in Mouse Model

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Are Senescent Cells Turning Your Hair Gray? A New Aging Theory