Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

How to Support Muscle Function with Age: Top Evidence-Based Supplements

Data suggest certain supplements, such as L-carnitine, vitamin D, and essential minerals, support muscle function and physical performance in adults of advanced age.

Researchers from University College London review data supporting that supplements, like vitamin D, L-carnitine, and essential minerals, support muscle function during aging.

Skin &amp; Muscle

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes 

On 60 Minutes, Peter Attia reveals how performance, prevention, and emotional resilience contribute to aging well. 

How American Country Music Icon Willie Nelson Has Defied Age Limitations into His 90s

Country music legend Willie Nelson practices martial arts to maintain physical function, keeps a positive outlook, and eats low amounts of food for astounding longevity.

(Willie Nelson [with American flag bandana] plays alongside Walon Jennings [left] and Johnny Cash [right] | YouTube)

Country music icon Willie Nelson does martial arts, stays positive, and keeps his calorie intake low for optimal aging into his 90s.

Search Result: Performance

New Study Shows Increasing COX7RP Improves Energy Production and Extends Lifespan

How to Boost Mitochondrial Density and Quality for Longevity

How to Support Muscle Function with Age: Top Evidence-Based Supplements

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes

How American Country Music Icon Willie Nelson Has Defied Age Limitations into His 90s