Model: SAMP8 mice 
Dosage: ~25 mg/kg/day of PQQ or PQI administered in food

Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


Aging &amp; Longevity

Model: Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.
Dosage: Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of Kluyveromyces fragilis yeast extract, 350 mg of Saccharomyces cerevisiae yeast extract, or a placebo.

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Human trials report that GlyNAC and exercise regimens improve dysfunction of the cell’s powerhouses (mitochondria), inflammation, muscle strength, and cognition.

(Some GlyNAC tablets above the chemical structure of GlyNAC | Vitamin Retailer)

GlyNAC supplementation and exercise alleviate mitochondrial dysfunction, lower inflammation, increase muscle strength, and bolster cognition.

Skin &amp; Muscle

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

What Is Mosaic Aging? How Organs Age at Different Rates

A new framework proposes that the patchwork nature of aging, where different organs deteriorate at different speeds, may hold the key to understanding the ultimate cause of death.

(University of Glasgow logo | Scotland.org)

A new framework proposes that aging occurs unevenly in cells, tissues, and organs, and that targeting the fastest-aging tissues may extend lifespan.

Search Result: Performance

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Rapamycin and Exercise: New Study Finds Potential Performance Decline

What Is Mosaic Aging? How Organs Age at Different Rates