Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Model: Male C57BL/6 mice given continuous alcohol for 4 weeks 
Dosage: 350 mg/kg/day of nicotinamide riboside chloride for 2 weeks

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide riboside (NR) counteracts neuronal damage caused by alcohol consumption in mice. 

Search Result: Oxidative Stress

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

NAD+ Supplement Counters Alcohol-Induced Brain Aging, According to New Study