<p>Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks </p>
<p>Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks</p>


High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

How to Boost Mitochondrial Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

Aging &amp; Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

How to Support Muscle Function with Age: Top Evidence-Based Supplements

Data suggest certain supplements, such as L-carnitine, vitamin D, and essential minerals, support muscle function and physical performance in adults of advanced age.

Researchers from University College London review data supporting that supplements, like vitamin D, L-carnitine, and essential minerals, support muscle function during aging.

Skin &amp; Muscle

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes 

On 60 Minutes, Peter Attia reveals how performance, prevention, and emotional resilience contribute to aging well. 

Search Result: Nutrition

High Protein Intake Promotes Aging by Lowering NAD+ Levels

How to Boost Mitochondrial Density and Quality for Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

How to Support Muscle Function with Age: Top Evidence-Based Supplements

Peter Attia’s 2025 Performance Principles for Longevity: 60 Minutes