Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Aging &amp; Longevity

Model: Male 16-month-old C57BL/6 mice 
Dosage: Intraperitoneal injection of 20 mg/kg/day of inosine for 4 weeks

Inosine Supplment Combats New Driver of Aging 

Scientists discover that inosine—a type of molecule called a purine nucleoside—alleviates multiple-organ aging in mice, and restores the oxygen delivery capacity of red blood cells. 


An artistic depiction of red blood cells delivering oxygen to surrounding tissues. 

Aging Guru Bryan Johnson’s Supplement List for 2026

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

(Bryan Johnson, who utilizes a continuously updated protocol to slow aging and optimize his body | Netflix)

Changes to Bryan Johnson’s updated 2026 supplement stack include taking NMN or NR six days a week instead of seven and removing rapamycin.

Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Brain &amp; Neurons

NAD+ Ranked #2 Most Powerful Anti-Aging Agent

Based on current scientific evidence, Dutch researchers have ranked existing anti-aging interventions based on how likely they are to protect against DNA damage and aging. 


On the far right, one of the researchers, Dr. Jan H.J. Hoeijmakers (image: amazinggerasmusmc.nl). 

Search Result: Nicotinamide Riboside

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

Inosine Supplment Counters New Driver of Aging

Aging Guru Bryan Johnson’s Supplement List for 2026

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

NAD+ Ranked #2 Most Powerful Way to Reverse DNA Damage & Aging