Model: Young acquired niacin dependency (ANDY) mice. 
Dosage: 30 mg/kg/day of niacin

Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


The NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) counters sleep-deprivation-induced cognitive deficits in rats with excess Alzheimer’s plaques. 


Brain &amp; Neurons

Japanese scientists have found that reducing NAD+ (nicotinamide adenine dinucleotide) transport into mitochondria within the fat tissue of mice induces metabolic dysregulation and obesity. 

Participants: Healthy adults 
Dosage: An escalating dose of niacin (250-1000 mg/day) for 16 weeks

Finnish scientists used a new measurement system to detect low NAD+ levels in blood samples from people with a range of age-related conditions, but not in healthy older individuals.


Principal Investigator of the study, Dr. Anu Suomalainen (image: helenski.fi).

Search Result: Niacin

New Mayo Clinic Study: Forcibly Depleting NAD+ Shortens Lifespan

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

NAD+ Booster Counters Cognitive Deficits of Sleep Deprivation, New Study Shows

NAD+ Transporter Prevents Obesity Caused by Aging: New Study Shows

NAD+ Levels in Healthy Aging: New Study Reveals Surprising Trends