University of Southern California (USC) scientists help to uncover why human intelligence declines with age, pointing to a newly discovered cellular target.


The principal investigator on the study, Dr. Michael Bonaguidi (image: usc.edu).

Brain &amp; Neurons

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Aging &amp; Longevity

Model: UM-HET3 Mice 
Dosage: 0, 75, 150, 300, 600, and 1200 ng epicatechin/mg food; 0, 0.075, 0.15, 0.3, 0.6, and 1.2 ng halofuginone/mg food; and 0, 37.5, 75, 150, 300, and 600 ng mitoglitazone/mg food, all given ad libitum in food starting at seven months old

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

(The three compounds’ effects on median lifespan extension | Rapamycin Longevity News)

The world’s most rigorous longevity study presents data showing promise for three new lifespan-extending compounds in male mice.

Search Result: Neuroscience

What Causes Age-Related Intelligence Decline? A New Study Points to Immature Brain Cells

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Three Compounds Show Promise for Male Longevity