Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Brain &amp; Neurons

Model: UM-HET3 mice and 5XFAD mice 
Dosage: UM=HET3 mice received 180 mg/kg canagliflozin in chow starting at seven months of age, and FXFAD mice received 180 mg/kg canagliflozin in chow beginning at three months of age

New Study: Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression

The diabetes drug canagliflozin improves learning and memory in middle-aged male mice and reduces brain plaques in Alzheimer’s model mice.

The FDA-approved diabetes medication canagliflozin improves cognition in a mouse model of Alzheimer’s disease in males only.

Restoring the essential molecule NAD+ may potentially hold the key to treating Alzheimer’s, as Harvard researchers emphasize the role of low brain NAD+ in this devastating disease.


Model: Healthy adults between 21 and 79 years of age 
Dosage: 395 mg/kg of bodyweight of (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate monoester (𝛽-hydroxybutyrate ketones) diluted in water and administered once

New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

A new study suggests that supplementing with ketones—molecules the body can use for energy when lacking sugars—prevents cognitive aging when administered in people’s 40s and 50s.

(The study’s principal investigator, Dr. Lilianne R. Mujica-Parodi | Stony Brook University News)

Based on age-related destabilized brain signaling, a new study suggests a critical midlife window where metabolic interventions may stabilize brain signaling.

Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

Search Result: Neurons

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study

Targeting NAD+ for Treating Dementia: New Harvard Op-Ed

New Study Finds Midlife May Be a Critical Window to Prevent Brain Aging

Accessing Technology that Reduces Alzheimer’s Memory Loss by 52%