Model: C57BL/6J mice 
Dosage: Eating only within an 8-hour window and fasting for 16 hours (~20% caloric deficit may be required)

Restricting food intake for 16 hours a day improves the health of female mice and moderately prolongs the life of male mice. 

The principal investigators of the study (from left to right): Dr. Carla Green, Dr. Victoria Acosta-Rodriguez, and Dr. Joseph Takahashi (image: dallasnews.com). 

Aging &amp; Longevity

Participants: Healthy adults 
Dosage: An escalating dose of niacin (250-1000 mg/day) for 16 weeks

Finnish scientists used a new measurement system to detect low NAD+ levels in blood samples from people with a range of age-related conditions, but not in healthy older individuals.


Principal Investigator of the study, Dr. Anu Suomalainen (image: helenski.fi).

Model: Female ICR (Institute of Cancer Research) mice
Dosage: ~240 mg/day of pterostilbene within food

Pterostilbene Promotes Fertility in Aged Females

The plant-based antioxidant, pterostilbene, improves egg quality in aged mice, as measured by an increase in live offspring. 

Blueberries are among the richest natural sources of pterostilbene. 

Dark Chocolate Compound Linked to Slower Aging, Study Finds

Elevated circulating theobromine—derived from cocoa—was associated with a slower pace of aging, according to two assessments.

(The molecular structure of theobromine | Forbes)

A compound derived from dark chocolate, theobromine, circulating at higher levels, is associated with a reduced pace of aging.

Epigenetics

Participants: Healthy male adults between the ages of 18 and 50 
Dosage: 714 mg/day of nicotinamide and 19 mg/day of pyridoxine for nine days

In a randomized human trial, combining nicotinamide with vitamin B6 increases stem cell activation and muscle-growth capacity in response to exercise. 

Search Result: Males

16-Hour Intermittent Fasting Improves Health and Longevity, New Study Confirms

NAD+ Levels in Healthy Aging: New Study Reveals Surprising Trends

Pterostilbene and Fertility: New Study on Restoring Reproductive Aging

Dark Chocolate Compound Linked to Slower Aging, Study Finds

NAD+ Booster and Vitamin B6 Activate Stem Cells to Counter Muscle Shrinkage, New Studies Show