Participants: Healthy males (age range: 70-76)
Dosage: 1 mg/kg/day of rapamycin for 8 weeks

Supplementing with rapamycin leads to improvements in cardiac and vascular function in older men, suggesting this longevity-associated drug may counteract cardiovascular aging. 

Nicolas Musi, MD, professor of medicine and an author of the study (image: sanantoniomag.com). 

Cardiovascular

University of California (UC) Berkeley scientists moderately extend the lifespan of old mice by giving them oxytocin (sometimes called the "love hormone") and a compound that inhibits inflammation.  

Aging &amp; Longevity

Model: UM-HET3 Mice 
Dosage: 0, 75, 150, 300, 600, and 1200 ng epicatechin/mg food; 0, 0.075, 0.15, 0.3, 0.6, and 1.2 ng halofuginone/mg food; and 0, 37.5, 75, 150, 300, and 600 ng mitoglitazone/mg food, all given ad libitum in food starting at seven months old

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

(The three compounds’ effects on median lifespan extension | Rapamycin Longevity News)

The world’s most rigorous longevity study presents data showing promise for three new lifespan-extending compounds in male mice.

A natural supplement, quercetin, targets age-promoting senescent cells, reduces inflammation, and counteracts blood vessel aging in men with heart disease. 

Study conducted at the University of Montreal in Quebec, Canada (image: ledevoir.com) 

Clinical Trials

Model: Ten-month-old male EFAD mice 
Dosage: 14.4 ppm of alfatradiol in diet for five months

USC Study: Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer's

The drug alfatradiol, also known as 17ɑ-estradiol, reduces cognitive errors on a test of memory and lowers neuronal plaques in mice genetically predisposed to Alzheimer’s disease.

(The University of Southern California | College Matchpoint)

Researchers unveil data suggesting the drug alfatradiol improves signs of frailty, reduces cognitive errors, and reduces neuronal plaques in mice with a genetic predisposition to Alzheimer’s disease.

Search Result: Males

Longevity Drug Rapamycin Improves the Heart of Older Adults, New Study Shows

New UC Berkeley Study: “Love Hormone” and Anti-Inflammatory Combo Extend Life

Three Compounds Show Promise for Male Longevity

A Natural Senolytic Supplement Curbs Heart Aging in New Clinical Trial

USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s