Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

Model: 22-month-old male C57BL/6NIH mice 
Dosage: 400 mg/kg of NR for eight weeks, administered in food

Treating aged mice with the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) improves memory and reduces pro-inflammatory immune cells.

Senior members of the research team, Dr. Bruce R. Troen and Dr. Kenneth L. Seldeen (image: buffalo.edu).  

Brain &amp; Neurons

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Seragon Biosciences has launched its new sleep and longevity optimizer, Enlivien, featuring technology based on a Harvard University collaboration. 


Supplements like NAD+ boosters may benefit older individuals, while drugs like metformin and interventions such as physical exercise may not, according to German scientists. 

Search Result: Lipid Metabolism

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan

NAD+ Supplement Improves Memory & Brain Immune Cells, New Study Reveals

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Enlivien: A New Dawn for Sleep and Longevity

New Findings: Anti-Aging Supplements Are Not “One-Size-Fits-All”