Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Aging &amp; Longevity

Dark Chocolate Compound Linked to Slower Aging, Study Finds

Elevated circulating theobromine—derived from cocoa—was associated with a slower pace of aging, according to two assessments.

(The molecular structure of theobromine | Forbes)

A compound derived from dark chocolate, theobromine, circulating at higher levels, is associated with a reduced pace of aging.

Epigenetics

The Rise of China’s Longevity Movement: A Quest to Defy Aging

China’s national project to crush aging encompasses longevity labs, “immortality islands,” and grapeseed pills, as well as exorbitant claims based on sometimes questionable science.

(Attendees at a conference in Shanghai try out a cryogenic chamber in which temperatures plummeted to approximately -200 degrees Fahrenheit, meant to slow aging | New York Times)

A surge in the Chinese public’s interest in longevity science has led to substantial investments from the state and private companies in aging research.

Johns Hopkins Research Review: Parkinson’s Drug Extends Multiple Species' Lifespan

L-deprenyl, a drug used to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend lifespan across species, from mice to rats to hamsters.

L-deprenyl, a drug prescribed to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend average lifespan across mammalian model organism species.

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

According to French scientists, no organ system appears as vulnerable to aging as the cardiovascular system, and anti-aging therapeutics may help mitigate the effects of cardiovascular disease.

(The principal investigator behind the review, aging researcher Guido Kroemer | Olympiad in Cardiovascular Medicine)

Anti-aging therapeutics may prevent and slow age-related cardiovascular dysfunction.

Search Result: Lifespan Extension

New Study Shows Increasing COX7RP Improves Energy Production and Extends Lifespan

Dark Chocolate Compound Linked to Slower Aging, Study Finds

The Rise of China’s Longevity Movement: A Quest to Defy Aging

Johns Hopkins Research Review: Parkinson’s Drug Shown to Extend Lifespan Across Mammalian Species

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease